Fonte
Revista do Instituto medicina tropical de São Paulo
Scientific Electronic Library Online ( SciELO)
Autoria
Marilia Ladeira de Araújo, Wellington Duarte, Augusto César Penalva de Oliveira, Maria Rita Polo Gascón ,Luiz Augusto Marcondes Fonseca,Raquel de Melo Alves Paiva, Bárbara Santana,Rodrigo Tocantins Calado Jorge Casseb
Resumo
Objective: We evaluated the association between cognitive deficits and leukocyte telomere
length (LTL) in HIV-1-infected individuals. Design: 73 HIV-1-infected patients undergoing
neuropsychological evaluation and 91 healthy controls were included in this study. Fifteen
HIV-1 positive patients did not have cognitive disorders whereas 26 had asymptomatic
neurocognitive disorder (ANI), 13 presented mild to moderate neurocognitive disorder
(MND), and 10 had HIV-associated dementia (HAD). Methods: DNA from the peripheral
blood of HIV-1-infected patients was used for measurement of telomere length by real-time
PCR. HIV-1 viral load was determined in blood. Results: LTL decreased with age in healthy
controls (p=0.0001). Regardless of the HIV status, age-matched LTL from HIV patients,
including those with ANI and MND, were shortened in comparison to the healthy control
group (p=0.0073); however, no association was found among the HIV-1-infected individuals
with cognitive deficits (p=0.01). In addition, no gender-related association with LTL was
observed (p=0.80), smoking, physical exercise, and plasma viral load were not correlated to
telomere length (p=0.66). Conclusions: We concluded that leukocyte telomere length may
not be a marker of cellular senescence in individuals with HIV infection and neurocognitive
disorders.
Is the telomere length associated with neurocognitive
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